Integrative analysis of epigenomic features—like open chromatin and DNA methylation—alongside genetic variation provides powerful insights into disease mechanisms and the discovery of novel biomarkers. Fiber-seq is an innovative long-read sequencing (LRS) technology that captures both genetic and epigenetic information across multi-kilobase DNA molecules at single-nucleotide, single-molecule, and even single-cell resolution. It uses the Hia5 adenine methyltransferase to mark open chromatin and regulatory regions with 6mA in vivo.

While Fiber-seq’s potential is clear, expanding access to key reagents, sequencing platforms, and analysis tools is essential to drive broader adoption. In this presentation, we’ll highlight how EpiCypher is addressing these challenges with commercial solutions that expand access to Fiber-seq—unlocking the full power of PacBio's new SPRQ chemistry to drive epigenomic discovery.