In an era defined by rapid advancements in precision medicine, immunogenomics has emerged as a powerful tool to unravel the complexities of immune responses and vaccine performance. Dr. Melissa Smith explores the cutting-edge strategies to decode the genetic and molecular foundations of immunity. Dr. Smith will highlight how HiFi reads and SPRQ chemistry advancements are driving breakthroughs in vaccine development, enabling researchers to predict efficacy, optimize formulations, and personalize immunization strategies. By identifying genetic markers of immune responsiveness, this talk will highlight methods that her team has developed to identify variations that underpin vaccine success—and failure.