This talk will discuss somatic structural variant detection in cases of pediatric leukemias and solid tumors using HiFi sequencing and a recently-published bioinformatics tool known as Severus. Topics will include the performance characteristics of this method for detecting simple and complex structural variants from whole-genome long-read sequence data with a focus on its potential for clinical use. The experiences of doing this using archived samples, as well as using both tumor-normal and tumor-only approaches, will also be discussed.